Resolution and Determination of the Absolute Stereochemistry of α and β-Aryl-Substituted γ-Methylenevalerolactones, Alternate Substrate Inhibitors for Serine Proteases

Keyphrases

• Aryl 100%
• Serine Protease 100%
• Alternative Substrates 100%
• Absolute Stereochemistry 100%
• 2-Pyranone 80%
• Amides 60%
• Phenyl 60%
• Lactones 60%
• Stereochemistry 40%
• Naphthyl 40%
• Homochiral 40%
• Enol Lactones 40%
• Phenylglycinol 40%
• Acetylenic Acid 40%
• Mercury 20%
• Acid Hydrolysis 20%
• 1H NMR Spectra 20%
• Chromatographic Separation 20%
• Absolute Configuration 20%
• Diastereomers 20%
• Chemical Shift 20%
• Silica Gel 20%
• Stereochemical Hypothesis 20%
• X-ray Crystallographic Analysis 20%
• Enantioselectivity 20%
• Chymotrypsin 20%
• Hydrolysis Products 20%
• Asymmetric Synthesis 20%
• Hydrazone 20%
• Triphenylphosphine Oxide 20%
• Enantiomeric Excess 20%
• Ilium 20%
• Substrate Inhibition 20%
• Amide Derivatives 20%
• Lactonization 20%
• Elution Order 20%
• Chromatographic Elution 20%

Chemistry

• Stereochemistry 100%
• Serine 100%
• Lactone 100%
• Carboxamide 80%
• 2-Pyranones 80%
• Enol 40%
• Enantiomer 40%
• Naphthalene 40%
• Acid Hydrolysis 20%
• Diastereomer 20%
• 1H NMR Spectrum 20%
• Absolute Configuration 20%
• Chromatography 20%
• Chemical Shift 20%
• X-Ray Crystallographic Analysis 20%
• Enantioselectivity 20%
• Triphenylphosphine 20%
• Asymmetric Synthesis 20%
• Hydrazone 20%
• Hexynoic Acid 20%
• 5-Oxohexanoic Acid 20%
• Enzymatic Hydrolysis 20%
• lactonization 20%