Replication-transcription conflicts in bacteria

Houra Merrikh, Yan Zhang, Alan D. Grossman, Jue D. Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

DNA replication and transcription use the same template and occur concurrently in bacteria. The lack of temporal and spatial separation of these two processes leads to their conflict, and failure to deal with this conflict can result in genome alterations and reduced fitness. In recent years major advances have been made in understanding how cells avoid conflicts between replication and transcription and how such conflicts are resolved when they do occur. In this Review, we summarize these findings, which shed light on the significance of the problem and on how bacterial cells deal with unwanted encounters between the replication and transcription machineries.

Original languageEnglish (US)
Pages (from-to)449-458
Number of pages10
JournalNature Reviews Microbiology
Volume10
Issue number7
DOIs
StatePublished - Jul 2012
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • General Immunology and Microbiology
  • Infectious Diseases

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