Relationship between systemic inflammation and delayed-type hypersensitivity response to Candida antigen in older adults

Brandt D. Pence, Thomas W. Lowder, K. Todd Keylock, Victoria J Vieira Potter, Marc D. Cook, Edward McAuley, Jeffrey A. Woods

Research output: Contribution to journalArticlepeer-review

Abstract

Research has shown that aging is associated with increased systemic inflammation as well as a reduction in the strength of immune responses. However, little evidence exists linking the decrease in cell-mediated immunity in older adults with other health parameters. We sought to examine the relationship between cell-mediated immunity as measured in vivo by the delayed-type hypersensitivity (DTH) response to candida antigen and demographic and physiological variables in older (65-80 y.o.) adults. Candida antigen response was not related to gender or obesity, or to a number of other physiological variables including fitness and body composition. However, positive responders had significantly lower serum C-reactive protein levels (CRP, p<0.05) vs. non-responders. Furthermore, subjects with CRP<4.75 mg•L-1 had greater odds of developing a positive response compared to those with CRP>4.75 mg•L-1. Therefore, positive responses to candida antigen in older adults appears to be related to lower levels of systemic inflammation.

Original languageEnglish (US)
Article numbere36403
JournalPloS one
Volume7
Issue number5
DOIs
StatePublished - May 2 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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