Relating Hippocampus to Relational Memory Processing across Domains and Delays

Jim M. Monti, Gillian E. Cooke, Patrick D. Watson, Michelle W. Voss, Arthur F. Kramer, Neal J. Cohen

Research output: Contribution to journalArticle

Abstract

The hippocampus has been implicated in a diverse set of cognitive domains and paradigms, including cognitive mapping, long-term memory, and relational memory, at long or short study-test intervals. Despite the diversity of these areas, their association with the hippocampus may rely on an underlying commonality of relational memory processing shared among them. Most studies assess hippocampal memory within just one of these domains, making it difficult to know whether these paradigms all assess a similar underlying cognitive construct tied to the hippocampus. Here we directly tested the commonality among disparate tasks linked to the hippocampus by using PCA on performance from a battery of 12 cognitive tasks that included two traditional, long-delay neuropsychological tests of memory and two laboratory tests of relational memory (one of spatial and one of visual object associations) that imposed only short delays between study and test. Also included were different tests of memory, executive function, and processing speed. Structural MRI scans from a subset of participants were used to quantify the volume of the hippocampus and other subcortical regions. Results revealed that the 12 tasks clustered into four components; critically, the two neuropsychological tasks of long-term verbal memory and the two laboratory tests of relational memory loaded onto one component. Moreover, bilateral hippocampal volume was strongly tied to performance on this component. Taken together, these data emphasize the important contribution the hippocampus makes to relational memory processing across a broad range of tasks that span multiple domains.

Original languageEnglish (US)
Pages (from-to)234-245
Number of pages12
JournalJournal of Cognitive Neuroscience
Volume27
Issue number2
DOIs
StatePublished - Mar 1 2014

Fingerprint

Hippocampus
Long-Term Memory
Passive Cutaneous Anaphylaxis
Neuropsychological Tests
Executive Function
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Relating Hippocampus to Relational Memory Processing across Domains and Delays. / Monti, Jim M.; Cooke, Gillian E.; Watson, Patrick D.; Voss, Michelle W.; Kramer, Arthur F.; Cohen, Neal J.

In: Journal of Cognitive Neuroscience, Vol. 27, No. 2, 01.03.2014, p. 234-245.

Research output: Contribution to journalArticle

Monti, Jim M. ; Cooke, Gillian E. ; Watson, Patrick D. ; Voss, Michelle W. ; Kramer, Arthur F. ; Cohen, Neal J. / Relating Hippocampus to Relational Memory Processing across Domains and Delays. In: Journal of Cognitive Neuroscience. 2014 ; Vol. 27, No. 2. pp. 234-245.
@article{06ef592479d349dca36232ea916a4908,
title = "Relating Hippocampus to Relational Memory Processing across Domains and Delays",
abstract = "The hippocampus has been implicated in a diverse set of cognitive domains and paradigms, including cognitive mapping, long-term memory, and relational memory, at long or short study-test intervals. Despite the diversity of these areas, their association with the hippocampus may rely on an underlying commonality of relational memory processing shared among them. Most studies assess hippocampal memory within just one of these domains, making it difficult to know whether these paradigms all assess a similar underlying cognitive construct tied to the hippocampus. Here we directly tested the commonality among disparate tasks linked to the hippocampus by using PCA on performance from a battery of 12 cognitive tasks that included two traditional, long-delay neuropsychological tests of memory and two laboratory tests of relational memory (one of spatial and one of visual object associations) that imposed only short delays between study and test. Also included were different tests of memory, executive function, and processing speed. Structural MRI scans from a subset of participants were used to quantify the volume of the hippocampus and other subcortical regions. Results revealed that the 12 tasks clustered into four components; critically, the two neuropsychological tasks of long-term verbal memory and the two laboratory tests of relational memory loaded onto one component. Moreover, bilateral hippocampal volume was strongly tied to performance on this component. Taken together, these data emphasize the important contribution the hippocampus makes to relational memory processing across a broad range of tasks that span multiple domains.",
author = "Monti, {Jim M.} and Cooke, {Gillian E.} and Watson, {Patrick D.} and Voss, {Michelle W.} and Kramer, {Arthur F.} and Cohen, {Neal J.}",
year = "2014",
month = "3",
day = "1",
doi = "10.1162/jocn_a_00717",
language = "English (US)",
volume = "27",
pages = "234--245",
journal = "Journal of Cognitive Neuroscience",
issn = "0898-929X",
publisher = "MIT Press Journals",
number = "2",

}

TY - JOUR

T1 - Relating Hippocampus to Relational Memory Processing across Domains and Delays

AU - Monti, Jim M.

AU - Cooke, Gillian E.

AU - Watson, Patrick D.

AU - Voss, Michelle W.

AU - Kramer, Arthur F.

AU - Cohen, Neal J.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - The hippocampus has been implicated in a diverse set of cognitive domains and paradigms, including cognitive mapping, long-term memory, and relational memory, at long or short study-test intervals. Despite the diversity of these areas, their association with the hippocampus may rely on an underlying commonality of relational memory processing shared among them. Most studies assess hippocampal memory within just one of these domains, making it difficult to know whether these paradigms all assess a similar underlying cognitive construct tied to the hippocampus. Here we directly tested the commonality among disparate tasks linked to the hippocampus by using PCA on performance from a battery of 12 cognitive tasks that included two traditional, long-delay neuropsychological tests of memory and two laboratory tests of relational memory (one of spatial and one of visual object associations) that imposed only short delays between study and test. Also included were different tests of memory, executive function, and processing speed. Structural MRI scans from a subset of participants were used to quantify the volume of the hippocampus and other subcortical regions. Results revealed that the 12 tasks clustered into four components; critically, the two neuropsychological tasks of long-term verbal memory and the two laboratory tests of relational memory loaded onto one component. Moreover, bilateral hippocampal volume was strongly tied to performance on this component. Taken together, these data emphasize the important contribution the hippocampus makes to relational memory processing across a broad range of tasks that span multiple domains.

AB - The hippocampus has been implicated in a diverse set of cognitive domains and paradigms, including cognitive mapping, long-term memory, and relational memory, at long or short study-test intervals. Despite the diversity of these areas, their association with the hippocampus may rely on an underlying commonality of relational memory processing shared among them. Most studies assess hippocampal memory within just one of these domains, making it difficult to know whether these paradigms all assess a similar underlying cognitive construct tied to the hippocampus. Here we directly tested the commonality among disparate tasks linked to the hippocampus by using PCA on performance from a battery of 12 cognitive tasks that included two traditional, long-delay neuropsychological tests of memory and two laboratory tests of relational memory (one of spatial and one of visual object associations) that imposed only short delays between study and test. Also included were different tests of memory, executive function, and processing speed. Structural MRI scans from a subset of participants were used to quantify the volume of the hippocampus and other subcortical regions. Results revealed that the 12 tasks clustered into four components; critically, the two neuropsychological tasks of long-term verbal memory and the two laboratory tests of relational memory loaded onto one component. Moreover, bilateral hippocampal volume was strongly tied to performance on this component. Taken together, these data emphasize the important contribution the hippocampus makes to relational memory processing across a broad range of tasks that span multiple domains.

UR - http://www.scopus.com/inward/record.url?scp=84920055392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920055392&partnerID=8YFLogxK

U2 - 10.1162/jocn_a_00717

DO - 10.1162/jocn_a_00717

M3 - Article

C2 - 25203273

AN - SCOPUS:84920055392

VL - 27

SP - 234

EP - 245

JO - Journal of Cognitive Neuroscience

JF - Journal of Cognitive Neuroscience

SN - 0898-929X

IS - 2

ER -