Regulators of membrane trafficking and Mycobacterium tuberculosis phagosome maturation block

Rutilio A. Fratti, Isabelle Vergne, Jennifer Chua, Jennifer Skidmore, Vojo Deretic

Research output: Contribution to journalArticlepeer-review

Abstract

The biogenesis and maturation of phagosomes is an area of study which has been employing aspects of proteomic analyses and variations on that theme by identifying components on isolated organelles and following their dynamic changes and interactions with the endocytic pathway. In the case of Mycobacterium tuberculosis phagosome, the arrest of its maturation in infected macrophages, referred to in classical texts as the inhibition of phagosome-lysosome fusion, represents a phenomenon that is used to functionally dissect the phagosomal maturation pathway. In this review, we summarize the recent studies on regulators of membrane trafficking and other organelle components in the context of phagosomal biogenesis and mycobacterial phagosome maturation arrest.

Original languageEnglish (US)
Pages (from-to)3378-3385
Number of pages8
JournalElectrophoresis
Volume21
Issue number16
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Coronin
  • Membrane trafficking
  • Mycobacterium tuberculosis
  • Phagosome maturation block
  • Review
  • SNARE
  • TACO

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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