An increase in the dosage of the fabA gene, which codes for the enzyme β hydroxydecanoyl thioesterase, caused an increase in the unsaturated fatty acyl content of the phospholipids. This increase was small in cells growing at a constant temperature. However, if cells grown at 37 or 42° were shifted to 15°, the rate of unsaturated fatty acyl moiety synthesis approached twice the rate of a normal strain. These results indicated that the ratio of unsaturated to saturated fatty acyl groups in phospholipids was partially determined by the levels of at least this fatty acid biosynthetic enzyme.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - 1974|
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