TY - JOUR
T1 - Regulation of the fatty acid composition of the membrane phospholipids of Escherichia coli
AU - Cronan, J. E.
PY - 1974
Y1 - 1974
N2 - An increase in the dosage of the fabA gene, which codes for the enzyme β hydroxydecanoyl thioesterase, caused an increase in the unsaturated fatty acyl content of the phospholipids. This increase was small in cells growing at a constant temperature. However, if cells grown at 37 or 42° were shifted to 15°, the rate of unsaturated fatty acyl moiety synthesis approached twice the rate of a normal strain. These results indicated that the ratio of unsaturated to saturated fatty acyl groups in phospholipids was partially determined by the levels of at least this fatty acid biosynthetic enzyme.
AB - An increase in the dosage of the fabA gene, which codes for the enzyme β hydroxydecanoyl thioesterase, caused an increase in the unsaturated fatty acyl content of the phospholipids. This increase was small in cells growing at a constant temperature. However, if cells grown at 37 or 42° were shifted to 15°, the rate of unsaturated fatty acyl moiety synthesis approached twice the rate of a normal strain. These results indicated that the ratio of unsaturated to saturated fatty acyl groups in phospholipids was partially determined by the levels of at least this fatty acid biosynthetic enzyme.
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U2 - 10.1073/pnas.71.9.3758
DO - 10.1073/pnas.71.9.3758
M3 - Article
C2 - 4610585
AN - SCOPUS:0016288114
SN - 0027-8424
VL - 71
SP - 3758
EP - 3762
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 9
ER -