Regulation of SIRT1 by microRNAs

Sung E. Choi; Jongsook Kim Kemper

doi:10.1007/s10059-013-0297-1

Regulation of SIRT1 by microRNAs

Sung E. Choi, Jongsook Kim Kemper

Molecular and Integrative Physiology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Sirtuin 1 (SIRT1) is an NAD⁺-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to benefit human health by preventing and improving many age-related diseases. There has been, therefore, substantial interest in developing agents that upregulate SIRT1 expression and activity. SIRT1 is regulated at multiple levels, including post- transcriptionally by microRNAs (miRs), powerful regulators of diverse biological pathways. Here we discuss how expression and activity of SIRT1 and other sirtuins are inhibited by miRs and further discuss the therapeutic potential of targeting miRs for age-related diseases that involve SIRT1 dysfunction, focusing on obesity-related diseases.

Original language	English (US)
Pages (from-to)	385-392
Number of pages	8
Journal	Molecules and Cells
Volume	36
Issue number	5
DOIs	https://doi.org/10.1007/s10059-013-0297-1
State	Published - Nov 2013

Keywords

Aging
Deacetylase
NAD
NAMPT
Obesity
Therapeutics

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Online availability

10.1007/s10059-013-0297-1

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title = "Regulation of SIRT1 by microRNAs",

abstract = "Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to benefit human health by preventing and improving many age-related diseases. There has been, therefore, substantial interest in developing agents that upregulate SIRT1 expression and activity. SIRT1 is regulated at multiple levels, including post- transcriptionally by microRNAs (miRs), powerful regulators of diverse biological pathways. Here we discuss how expression and activity of SIRT1 and other sirtuins are inhibited by miRs and further discuss the therapeutic potential of targeting miRs for age-related diseases that involve SIRT1 dysfunction, focusing on obesity-related diseases.",

keywords = "Aging, Deacetylase, NAD, NAMPT, Obesity, Therapeutics",

author = "Choi, {Sung E.} and Kemper, {Jongsook Kim}",

note = "Funding Information: The published work in the laboratory of authors at the Univrsity of Illinois at Urbana-Champaign, USA, was supported by grants from NIH DK95842 and DK62777 to JK. SC is currently at the Ajou University, Korea, and supported by the National Research Foundation, Korea, NRF-2013-013774. We thank Byron Kemper for reading the manuscript.",

year = "2013",

month = nov,

doi = "10.1007/s10059-013-0297-1",

language = "English (US)",

volume = "36",

pages = "385--392",

journal = "Molecules and Cells",

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number = "5",

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TY - JOUR

T1 - Regulation of SIRT1 by microRNAs

AU - Choi, Sung E.

AU - Kemper, Jongsook Kim

N1 - Funding Information: The published work in the laboratory of authors at the Univrsity of Illinois at Urbana-Champaign, USA, was supported by grants from NIH DK95842 and DK62777 to JK. SC is currently at the Ajou University, Korea, and supported by the National Research Foundation, Korea, NRF-2013-013774. We thank Byron Kemper for reading the manuscript.

PY - 2013/11

Y1 - 2013/11

N2 - Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to benefit human health by preventing and improving many age-related diseases. There has been, therefore, substantial interest in developing agents that upregulate SIRT1 expression and activity. SIRT1 is regulated at multiple levels, including post- transcriptionally by microRNAs (miRs), powerful regulators of diverse biological pathways. Here we discuss how expression and activity of SIRT1 and other sirtuins are inhibited by miRs and further discuss the therapeutic potential of targeting miRs for age-related diseases that involve SIRT1 dysfunction, focusing on obesity-related diseases.

AB - Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to benefit human health by preventing and improving many age-related diseases. There has been, therefore, substantial interest in developing agents that upregulate SIRT1 expression and activity. SIRT1 is regulated at multiple levels, including post- transcriptionally by microRNAs (miRs), powerful regulators of diverse biological pathways. Here we discuss how expression and activity of SIRT1 and other sirtuins are inhibited by miRs and further discuss the therapeutic potential of targeting miRs for age-related diseases that involve SIRT1 dysfunction, focusing on obesity-related diseases.

KW - Aging

KW - Deacetylase

KW - NAD

KW - NAMPT

KW - Obesity

KW - Therapeutics

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U2 - 10.1007/s10059-013-0297-1

DO - 10.1007/s10059-013-0297-1

M3 - Short survey

C2 - 24213676

AN - SCOPUS:84900423595

SN - 1016-8478

VL - 36

SP - 385

EP - 392

JO - Molecules and Cells

JF - Molecules and Cells

IS - 5

ER -

Regulation of SIRT1 by microRNAs

Abstract

Keywords

ASJC Scopus subject areas

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