Regulation of messenger RNA stability in eukaryotic cells

David J. Shapiro, John E. Blume, David A. Nielsen

Research output: Contribution to journalReview articlepeer-review


Regulation of the cytoplasmic stability of mRNAs has recetly been identified as a major control mechanism which governs mRNA levels in a variety of eukaryotic systems. In this review we discuss what is known about several experimental systems that exhibit regulated mRNA stability, describe the mechanisms that cells may use to achieve control of mRNA degradation, and suggest areas of future investigation likely to provide new insights into this process.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
Issue number5
StatePublished - May 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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