Regulation of Membrane Phospholipid Synthesis by the relA Gene: Dependence on ppgpp Levels

William D. Nunn, John E. Cronan

Research output: Contribution to journalArticlepeer-review

Abstract

A series of experiments using a pair of isogenic rel+ strains of Escherichia coli differing only in the spoT locus has demonstrated a quantitative correlation between the inhibition of phospholipid synthesis and the intracellular level of ppGpp. The conditions examined were (1) amino acid starvation; (2) release from amino acid starvation; and (3) balanced growth. We also have been shown the presence of a third gene (in addition to relA and spoT) concerned with ppGpp metabolism and have found that the level of ppGpp during amino acid starvation is unaffected by an increase in the dosage of the relA gene.

Original languageEnglish (US)
Pages (from-to)2546-2550
Number of pages5
JournalBiochemistry
Volume15
Issue number12
DOIs
StatePublished - Jun 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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