Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway

Keyphrases

• Chronic Inflammation 11%
• Downstream Effectors 11%
• Ectopic Expression 11%
• Glycogen Synthesis 11%
• Hepatic Insulin Resistance 100%
• Hepatoma Cells 11%
• HepG2 11%
• Inflammatory Cytokines 11%
• Insulin Receptor Substrate 1 (IRS1) 22%
• Insulin Resistance 22%
• Insulin Sensitivity 22%
• Insulin Signaling 33%
• Interleukin-6 100%
• Interleukin-6 Inhibitors 33%
• Mammalian Target of Rapamycin (mTOR) 100%
• Mammalian Target of Rapamycin Signaling 22%
• Mouse Primary Hepatocytes 11%
• Obesity 11%
• Pathological Conditions 11%
• Phosphorylation 22%
• Rapamycin 33%
• RNA Interference 11%
• S6 Kinase 1 (S6K1) 55%
• Serine Phosphorylation 11%
• STAT3 Activation 11%
• Suppressor of Cytokine Signaling 3 (SOCS3) 100%
• Transcriptional Activity 11%

Biochemistry, Genetics and Molecular Biology

• Ectopic Expression 8%
• Glycogenesis 8%
• Hepatocyte 8%
• Insulin Receptor 16%
• Insulin Resistance 100%
• Insulin Sensitivity 16%
• Insulin Signaling 25%
• Interleukin 6 100%
• Kinase 33%
• Mechanistic Target of Rapamycin 100%
• Mediator 8%
• Mouse 8%
• Phosphotransferase 33%
• Proinflammatory Cytokine 8%
• Ribosomal S6 Kinase 8%
• RNA Interference 8%
• Serine 8%
• SOCS3 100%
• STAT3 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Chronic Inflammation 8%
• Cytokine 8%
• Insulin Receptor Substrate 8%
• Insulin Receptor Substrate 1 8%
• Insulin Resistance 100%
• Interleukin 6 100%
• Liver Cell Carcinoma 8%
• Mammalian Target of Rapamycin 100%
• Mouse 8%
• Rapamycin 25%
• S6 Kinase 41%
• Serine 8%