Regulation of gene expression during adipocyte differentiation: a review.

H Rex Gaskins, G. J. Hausman, R. J. Martin

Research output: Contribution to journalReview article

Abstract

The differentiation of adipose precursor cells is accompanied by the acquisition of adipocyte-specific messenger (m) RNAs allowing characteristic changes in protein composition. The development of methods for cloning and characterizing individual genes has provided the opportunity to study selective gene expression by adipocytes at the molecular level. In this review, the information obtained to date regarding transcriptional and post-transcriptional regulatory mechanisms utilized by adipocytes is summarized. Included are descriptions of conserved DNA sequences found in noncoding regions of adipose genes and of how protein-DNA interactions at these regions are thought to regulate the initiation of transcription. Among the transcription factors implemented in regulation of adipocyte-specific gene expression are the protein product of the proto-oncogene c-fos, the triiodothyronine receptor and steroid hormone receptors. Data also are discussed that indicate that RNA editing and determinants of mRNA stability contribute to the adipocyte phenotype. It is hoped that a review of the regulatory aspects of gene expression during adipocyte differentiation will identify areas deserving further study by researchers interested in understanding adipose development.

Original languageEnglish (US)
Pages (from-to)2263-2272
Number of pages10
JournalJournal of animal science
Volume67
Issue number9
DOIs
StatePublished - Sep 1989
Externally publishedYes

Fingerprint

gene expression regulation
Gene Expression Regulation
adipocytes
Adipocytes
Gene Expression
gene expression
Proto-Oncogene Proteins c-fos
RNA Editing
RNA editing
proto-oncogenes
Thyroid Hormone Receptors
Proteins
Conserved Sequence
Steroid Receptors
protein products
RNA Stability
protein composition
Regulator Genes
Organism Cloning
molecular cloning

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

Cite this

Regulation of gene expression during adipocyte differentiation : a review. / Gaskins, H Rex; Hausman, G. J.; Martin, R. J.

In: Journal of animal science, Vol. 67, No. 9, 09.1989, p. 2263-2272.

Research output: Contribution to journalReview article

Gaskins, H Rex ; Hausman, G. J. ; Martin, R. J. / Regulation of gene expression during adipocyte differentiation : a review. In: Journal of animal science. 1989 ; Vol. 67, No. 9. pp. 2263-2272.
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