Regulation of food intake by inflammatory cytokines in the brain

Jessica B. Buchanan, Rodney W. Johnson

Research output: Contribution to journalReview articlepeer-review

Abstract

A number of inflammatory cytokines are synthesized and released after activation of the immune system. In addition to other biological effects, these cytokines can potently inhibit food intake. Cytokine-mediated inhibition of food intake is of particular importance because excessive production of peripheral inflammatory cytokines is often associated with the cachexia-anorexia syndrome seen in some chronic diseases. The weight loss in cachexia is associated with an increase in morbidity and mortality. Understanding how cytokines regulate food intake may be crucial in enhancing quality of life and facilitating recovery in patients exhibiting cachexia. This review describes the main inflammatory cytokines that influence food intake and explores how peripheral cytokines communicate with hypothalamic nuclei to influence feeding.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalNeuroendocrinology
Volume86
Issue number3
DOIs
StatePublished - Nov 2007

Keywords

  • Cachexia
  • Feeding
  • Hypothalamus
  • Inflammatory cytokines

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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