Regulation of bacterial metabolism by small RNAs using diverse mechanisms

Maksym Bobrovskyy, Carin K. Vanderpool

Research output: Contribution to journalReview article

Abstract

Bacteria live in many dynamic environments with alternating cycles of feast or famine that have resulted in the evolution of mechanisms to quickly alter their metabolic capabilities. Such alterations often involve complex regulatory networks that modulate expression of genes involved in nutrient uptake and metabolism. A great number of protein regulators of metabolism have been characterized in depth. However, our ever-increasing understanding of the roles played by RNA regulators has revealed far greater complexity to regulation of metabolism in bacteria. Here, we review the mechanisms and functions of selected bacterial RNA regulators and discuss their importance in modulating nutrient uptake as well as primary and secondary metabolic pathways.

Original languageEnglish (US)
Pages (from-to)209-232
Number of pages24
JournalAnnual Review of Genetics
Volume47
DOIs
StatePublished - Nov 2013

Keywords

  • Hfq
  • RNase E
  • Riboswitch
  • SgrS
  • Spot 42

ASJC Scopus subject areas

  • Genetics

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