Regulating bone formation via controlled scaffold degradation

E. Alsberg, H. J. Kong, Y. Hirano, M. K. Smith, A. Albeiruti, D. J. Mooney

Research output: Contribution to journalArticlepeer-review

Abstract

It is widely assumed that coupling the degradation rate of polymers used as cell transplantation carriers to the growth rate of the developing tissue will improve its quantity or quality. To test this hypothesis, we developed alginate hydrogels with a range of degradation rates by gamma-irradiating high-molecular-weight alginate to yield polymers of various molecular weights and structures. Decreasing the size of the polymer chains increased the degradation rate in vivo, as measured by implant retrieval rates, masses, and elastic moduli. Rapidly and slowly degrading alginates, covalently modified with RGD-containing peptides to control cell behavior, were then used to investigate the effect of biodegradation rate on bone tissue development in vivo. The more rapidly degrading gels led to dramatic increases in the extent and quality of bone formation. These results indicate that biomaterial degradability is a critical design criterion for achieving optimal tissue regeneration with cell transplantation.

Original languageEnglish (US)
Pages (from-to)903-908
Number of pages6
JournalJournal of Dental Research
Volume82
Issue number11
DOIs
StatePublished - Nov 2003
Externally publishedYes

Keywords

  • Alginate
  • Biomaterials
  • Irradiation
  • Osteoblasts
  • Tissue engineering

ASJC Scopus subject areas

  • Dentistry(all)

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