Regio- and chemoselective intermolecular hydroamination of allyl imines for the synthesis of 1,2-diamines

Andrew R. Ickes, Seth C. Ensign, Anil K. Gupta, Kami L. Hull

Research output: Contribution to journalArticle

Abstract

The synthesis of 1,2-diamines via a Rh-catalyzed intermolecular hydroamination of N-allyl imines with cyclic amines is presented. Coordinating groups proximal to the olefin bind to the catalyst and promote the transformation. The reaction affords 1,2-diamines in very good yields and is functional-group-tolerant and highly diastereoselective.

Original languageEnglish (US)
Pages (from-to)11256-11259
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number32
DOIs
StatePublished - Aug 13 2014

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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