Regeneration of cofactors for use in biocatalysis

Research output: Contribution to journalReview articlepeer-review


Cofactor-dependent enzymes catalyze many synthetically useful reactions. The high cost of cofactors, however, necessitates in situ cofactor regeneration for preparative applications. After two decades of research, several cofactors can now be effectively regenerated using enzyme or whole-cell based methods. Significant advances have been made in this area in the past three years and include the development of novel or improved methods for regenerating ATP, sugar nucleotides and 3-phosphoadenosine-5′-phosphosulphate. These approaches have found novel applications in biocatalysis.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalCurrent Opinion in Biotechnology
Issue number6
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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