Refractive index sensitive, plasmon resonant scattering, and surface enhanced Raman scattering nanoparticles and arrays as biological sensing platforms

Douglas A. Stuart, Amanda Haes, Adam D. McFarland, Shuming Nie, Richard P. Van Duyne

Research output: Contribution to journalConference article

Abstract

The intense color of noble metal nanoparticles has inspired artists and fascinated scientists for hundreds of years. These rich hues are due to the interaction of light with the nanostructure's localized surface plasmon (LSPR). Here, we describe three optical sensing modalities that are dependant on the effects of the LSPR. Specifically, we will demonstrate the use of LSPR supporting particles as analogues to fluorescent probes and labels for multiplex detection, sensing based on observation of changes in the LSPR spectrum caused by alteration of the local refractive index upon analyte binding, and the spectroscopic labeling of cells and tissues with Surface Enhanced Raman Scatting (SERS) active nanoparticles probes.

Original languageEnglish (US)
Pages (from-to)60-73
Number of pages14
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5327
DOIs
StatePublished - Nov 16 2004
Externally publishedYes
EventPlasmonics in Biology and Medicine - San Jose, CA, United States
Duration: Jan 26 2004Jan 27 2004

Keywords

  • Biosensor
  • Nanoparticle
  • SERS
  • Surface enhanced raman
  • Surface plasmon

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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