Reducing falls and improving mobility in multiple sclerosis

Jacob J. Sosnoff, Jonghun Sung

Research output: Contribution to journalReview articlepeer-review


Falls are common in persons with multiple sclerosis (MS), and are related to physical injury and reduce the quality of life. Mobility impairments are a significant risk factor for falls in persons with MS. Although there is evidence that mobility in persons with MS can be improved with rehabilitation, much less is known about fall prevention. This review focuses on fall prevention in persons with MS. Ten fall prevention interventions consisting of 524 participants with a wide range of disability were systematically identified. Nine of the 10 investigations report a reduction in falls and/or proportion of fallers following treatment. The vast majority observed an improvement in balance that co-occurred with the reduction in falls. Methodological limitations preclude any firm conclusions. Numerous gaps in the understanding of fall prevention in persons with MS are discussed. Well-designed randomized control trials targeting mobility and falls are warranted.

Original languageEnglish (US)
Pages (from-to)655-666
Number of pages12
JournalExpert Review of Neurotherapeutics
Issue number6
StatePublished - Jun 1 2015


  • balance
  • clinical trials
  • exercise
  • falls prevention
  • locomotion
  • mobility
  • rehabilitation
  • walking

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology
  • Pharmacology (medical)


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