Abstract
We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.
Original language | English (US) |
---|---|
Pages (from-to) | 1061-1065 |
Number of pages | 5 |
Journal | Biomaterials Science |
Volume | 3 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2015 |
ASJC Scopus subject areas
- Biomedical Engineering
- Materials Science(all)