Redox-responsive self-assembled chain-shattering polymeric therapeutics

Kaimin Cai, Jonathan Yen, Qian Yin, Yang Liu, Ziyuan Song, Stéphane Lezmi, Yanfeng Zhang, Xujuan Yang, William G. Helferich, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review

Abstract

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)1061-1065
Number of pages5
JournalBiomaterials Science
Volume3
Issue number7
DOIs
StatePublished - Jul 1 2015

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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