Redox-responsive self-assembled chain-shattering polymeric therapeutics

Kaimin Cai; Jonathan Yen; Qian Yin; Yang Liu; Ziyuan Song; Stephane Lezmi; Yanfeng Zhang; Xujuan Yang; William G. Helferich; Jianjun Cheng

doi:10.1039/c4bm00452c

Redox-responsive self-assembled chain-shattering polymeric therapeutics

Kaimin Cai, Jonathan Yen, Qian Yin, Yang Liu, Ziyuan Song, Stephane Lezmi, Yanfeng Zhang, Xujuan Yang, William G. Helferich, Jianjun Cheng

Research output: Contribution to journal › Article › peer-review

Abstract

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

Original language	English (US)
Pages (from-to)	1061-1065
Number of pages	5
Journal	Biomaterials Science
Volume	3
Issue number	7
DOIs	https://doi.org/10.1039/c4bm00452c
State	Published - Jul 1 2015

ASJC Scopus subject areas

Biomedical Engineering
Materials Science(all)

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10.1039/c4bm00452c

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abstract = "We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via {"}Click{"} reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.",

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AU - Cai, Kaimin

AU - Yen, Jonathan

AU - Yin, Qian

AU - Liu, Yang

AU - Song, Ziyuan

AU - Lezmi, Stephane

AU - Zhang, Yanfeng

AU - Yang, Xujuan

AU - Helferich, William G.

AU - Cheng, Jianjun

PY - 2015/7/1

Y1 - 2015/7/1

N2 - We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

AB - We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

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Redox-responsive self-assembled chain-shattering polymeric therapeutics

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