Redox-responsive, core cross-linked polyester micelles

Zhonghai Zhang, Lichen Yin, Chunlai Tu, Ziyuan Song, Yanfeng Zhang, Yunxiang Xu, Rong Tong, Qin Zhou, Jie Ren, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review


Monomethoxy poly(ethylene glycol)-b-poly(Tyr(alkynyl)-OCA), a biodegradable amphiphilic block copolymer, was synthesized by means of ring-opening polymerization of 5-(4-(prop-2-yn-1-yloxy)benzyl)-1,3-dioxolane-2,4-dione (Tyr(alkynyl)-OCA) and used to prepare core cross-linked polyester micelles via click chemistry. Core cross-linking not only improved the structural stability of the micelles, but also allowed controlled release of cargo molecules in response to the reducing reagent. This new class of core cross-linked micelles can potentially be used in controlled release and drug delivery applications.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalACS Macro Letters
Issue number1
StatePublished - Jan 15 2013

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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