Redox-responsive, core-cross-linked micelles capable of on-demand, concurrent drug release and structure disassembly

Hua Wang, Li Tang, Chunlai Tu, Ziyuan Song, Qian Yin, Lichen Yin, Zhonghai Zhang, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review

Abstract

We developed camptothecin (CPT)-conjugated, core-cross-linked (CCL) micelles that are subject to redox-responsive cleavage of the built-in disulfide bonds, resulting in disruption of the micellar structure and rapid release of CPT. CCL micelles were prepared via coprecipitation of disulfide-containing CPT-poly(tyrosine(alkynyl)-OCA) conjugate and monomethoxy poly(ethylene glycol)-b-poly(tyrosine(alkynyl)-OCA), followed by cross-linking of the micellar core via azide-alkyne click chemistry. CCL micelles exhibited excellent stability under physiological conditions, while they underwent rapid dissociation in reduction circumstance, resulting in burst release of CPT. These redox-responsive CCL micelles showed enhanced cytotoxicity against human breast cancer cells in vitro.

Original languageEnglish (US)
Pages (from-to)3706-3712
Number of pages7
JournalBiomacromolecules
Volume14
Issue number10
DOIs
StatePublished - Oct 14 2013

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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