Redox control of the transsulfuration and glutathione biosynthesis pathways.

Bart Deplancke, H. Rex Gaskins

Research output: Contribution to journalReview articlepeer-review


Intracellular reduction-oxidation status is increasingly recognized as a primary regulator of cellular growth and development. The relative reduction-oxidation state of the cell depends primarily on the precise balance between concentrations of reactive oxygen species and the cysteine-dependent antioxidant thiol buffers glutathione and thioredoxin, which by preferentially reacting with reactive oxygen species, protect other intracellular molecules from oxidative damage. The transsulfuration pathway constitutes the major route of cysteine biosynthesis, and may thus be central in controlling the intracellular reduction-oxidation state and the balance between self-renewal and differentiation programs. This review discusses new findings on reciprocal reduction-oxidation modulation of enzymes involved in the transsulfuration and glutathione biosynthesis pathways, as well as studies elucidating the impact of sulfur amino acid availability on these pathways.

Original languageEnglish (US)
Pages (from-to)85-92
Number of pages8
JournalCurrent opinion in clinical nutrition and metabolic care
Issue number1
StatePublished - Jan 2002

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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