Recursive nonparametric testing for dose-response relaflonships subject to downturns at high doses

Douglas G. Simpson; Barry H. Margolin

doi:10.1093/biomet/73.3.589

Recursive nonparametric testing for dose-response relaflonships subject to downturns at high doses

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Abstract

A general recursive strategy is introduced to test nonparametrically for an increasing dose-response relationship when a downturn in response at high doses is possible. A specific implementation involving a test of Jonckheere (1954) and Terpstra (1952) is considered, and its size and power properties are investigated via Monte Carlo methods. Data from mutation research illustrate the phenomenon of concern.

Original language	English (US)
Pages (from-to)	589-596
Number of pages	8
Journal	Biometrika
Volume	73
Issue number	3
DOIs	https://doi.org/10.1093/biomet/73.3.589
State	Published - Dec 1986

Keywords

Dose-response curve
Jonckheere-Terpstra test
Nonparametric test
Recursive test
Stochastic ordering

ASJC Scopus subject areas

Statistics and Probability
General Mathematics
Agricultural and Biological Sciences (miscellaneous)
General Agricultural and Biological Sciences
Statistics, Probability and Uncertainty
Applied Mathematics

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10.1093/biomet/73.3.589

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KW - Stochastic ordering

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Recursive nonparametric testing for dose-response relaflonships subject to downturns at high doses

Abstract

Keywords

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