Recursive nonparametric testing for dose-response relaflonships subject to downturns at high doses

Douglas G Simpson, Barry H. Margolin

Research output: Contribution to journalArticlepeer-review

Abstract

A general recursive strategy is introduced to test nonparametrically for an increasing dose-response relationship when a downturn in response at high doses is possible. A specific implementation involving a test of Jonckheere (1954) and Terpstra (1952) is considered, and its size and power properties are investigated via Monte Carlo methods. Data from mutation research illustrate the phenomenon of concern.

Original languageEnglish (US)
Pages (from-to)589-596
Number of pages8
JournalBiometrika
Volume73
Issue number3
DOIs
StatePublished - Dec 1 1986

Keywords

  • Dose-response curve
  • Jonckheere-Terpstra test
  • Nonparametric test
  • Recursive test
  • Stochastic ordering

ASJC Scopus subject areas

  • Statistics and Probability
  • Mathematics(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Agricultural and Biological Sciences(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics

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