Recurrent activity in neuronal avalanches

Tyler Salners, Karina E. Avila, Benjamin Nicholson, Christopher R. Myers, John Beggs, Karin A. Dahmen

Research output: Contribution to journalArticlepeer-review


A new statistical analysis of large neuronal avalanches observed in mouse and rat brain tissues reveals a substantial degree of recurrent activity and cyclic patterns of activation not seen in smaller avalanches. To explain these observations, we adapted a model of structural weakening in materials. In this model, dynamical weakening of neuron firing thresholds closely replicates experimental avalanche size distributions, firing number distributions, and patterns of cyclic activity. This agreement between model and data suggests that a mechanism like dynamical weakening plays a key role in recurrent activity found in large neuronal avalanches. We expect these results to illuminate the causes and dynamics of large avalanches, like those seen in seizures.

Original languageEnglish (US)
Article number4871
JournalScientific reports
Issue number1
StatePublished - Dec 2023
Externally publishedYes

ASJC Scopus subject areas

  • General


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