Reconfiguration of brain networks supporting inhibition of emotional challenge

Morgan E. Bartholomew, Cindy M. Yee, Wendy Heller, Gregory A. Miller, Jeffrey M. Spielberg

Research output: Contribution to journalArticle

Abstract

Reacting to the salient emotional features of a stimulus is adaptive unless the information is irrelevant or interferes with goal-directed behavior. The ability to ignore salient but otherwise extraneous information involves restructuring of brain networks and is a key impairment in several psychological disorders. Despite the importance of understanding inhibitory control of emotional response, the associated brain network mechanisms remain unknown. Utilizing functional magnetic resonance imaging (fMRI) data obtained from 103 participants performing an emotion-word Stroop (EWS) task, the present study applied graph-theory analysis to identify how brain regions subserving emotion processing and cognitive control are integrated within the global brain network to promote more specialized and efficient processing during successful inhibition of response to emotional distractors. The present study identified two sub-networks associated with emotion inhibition, one involving hyper-connectivity to prefrontal cortex and one involving hyper-connectivity to thalamus. Brain regions typically associated with identifying emotion salience were more densely connected with the thalamic hub, consistent with thalamic amplification of prefrontal cortex control of these regions. Additionally, stimuli high in emotional arousal prompted restructuring of the global network to increase clustered processing and overall communication efficiency. These results provide evidence that inhibition of emotion relies on interactions between cognitive control and emotion salience sub-networks.

Original languageEnglish (US)
Pages (from-to)350-357
Number of pages8
JournalNeuroImage
Volume186
DOIs
StatePublished - Feb 1 2019

Fingerprint

Emotions
Brain
Prefrontal Cortex
Aptitude
Arousal
Thalamus
Inhibition (Psychology)
Communication
Magnetic Resonance Imaging
Psychology
Efficiency

Keywords

  • Connectivity
  • Emotion
  • Graph theory
  • Inhibitory control
  • fMRI

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Reconfiguration of brain networks supporting inhibition of emotional challenge. / Bartholomew, Morgan E.; Yee, Cindy M.; Heller, Wendy; Miller, Gregory A.; Spielberg, Jeffrey M.

In: NeuroImage, Vol. 186, 01.02.2019, p. 350-357.

Research output: Contribution to journalArticle

Bartholomew, Morgan E. ; Yee, Cindy M. ; Heller, Wendy ; Miller, Gregory A. ; Spielberg, Jeffrey M. / Reconfiguration of brain networks supporting inhibition of emotional challenge. In: NeuroImage. 2019 ; Vol. 186. pp. 350-357.
@article{b9bfce8c949a4c5f93835bb7cfb07573,
title = "Reconfiguration of brain networks supporting inhibition of emotional challenge",
abstract = "Reacting to the salient emotional features of a stimulus is adaptive unless the information is irrelevant or interferes with goal-directed behavior. The ability to ignore salient but otherwise extraneous information involves restructuring of brain networks and is a key impairment in several psychological disorders. Despite the importance of understanding inhibitory control of emotional response, the associated brain network mechanisms remain unknown. Utilizing functional magnetic resonance imaging (fMRI) data obtained from 103 participants performing an emotion-word Stroop (EWS) task, the present study applied graph-theory analysis to identify how brain regions subserving emotion processing and cognitive control are integrated within the global brain network to promote more specialized and efficient processing during successful inhibition of response to emotional distractors. The present study identified two sub-networks associated with emotion inhibition, one involving hyper-connectivity to prefrontal cortex and one involving hyper-connectivity to thalamus. Brain regions typically associated with identifying emotion salience were more densely connected with the thalamic hub, consistent with thalamic amplification of prefrontal cortex control of these regions. Additionally, stimuli high in emotional arousal prompted restructuring of the global network to increase clustered processing and overall communication efficiency. These results provide evidence that inhibition of emotion relies on interactions between cognitive control and emotion salience sub-networks.",
keywords = "Connectivity, Emotion, Graph theory, Inhibitory control, fMRI",
author = "Bartholomew, {Morgan E.} and Yee, {Cindy M.} and Wendy Heller and Miller, {Gregory A.} and Spielberg, {Jeffrey M.}",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.neuroimage.2018.10.066",
language = "English (US)",
volume = "186",
pages = "350--357",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Reconfiguration of brain networks supporting inhibition of emotional challenge

AU - Bartholomew, Morgan E.

AU - Yee, Cindy M.

AU - Heller, Wendy

AU - Miller, Gregory A.

AU - Spielberg, Jeffrey M.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Reacting to the salient emotional features of a stimulus is adaptive unless the information is irrelevant or interferes with goal-directed behavior. The ability to ignore salient but otherwise extraneous information involves restructuring of brain networks and is a key impairment in several psychological disorders. Despite the importance of understanding inhibitory control of emotional response, the associated brain network mechanisms remain unknown. Utilizing functional magnetic resonance imaging (fMRI) data obtained from 103 participants performing an emotion-word Stroop (EWS) task, the present study applied graph-theory analysis to identify how brain regions subserving emotion processing and cognitive control are integrated within the global brain network to promote more specialized and efficient processing during successful inhibition of response to emotional distractors. The present study identified two sub-networks associated with emotion inhibition, one involving hyper-connectivity to prefrontal cortex and one involving hyper-connectivity to thalamus. Brain regions typically associated with identifying emotion salience were more densely connected with the thalamic hub, consistent with thalamic amplification of prefrontal cortex control of these regions. Additionally, stimuli high in emotional arousal prompted restructuring of the global network to increase clustered processing and overall communication efficiency. These results provide evidence that inhibition of emotion relies on interactions between cognitive control and emotion salience sub-networks.

AB - Reacting to the salient emotional features of a stimulus is adaptive unless the information is irrelevant or interferes with goal-directed behavior. The ability to ignore salient but otherwise extraneous information involves restructuring of brain networks and is a key impairment in several psychological disorders. Despite the importance of understanding inhibitory control of emotional response, the associated brain network mechanisms remain unknown. Utilizing functional magnetic resonance imaging (fMRI) data obtained from 103 participants performing an emotion-word Stroop (EWS) task, the present study applied graph-theory analysis to identify how brain regions subserving emotion processing and cognitive control are integrated within the global brain network to promote more specialized and efficient processing during successful inhibition of response to emotional distractors. The present study identified two sub-networks associated with emotion inhibition, one involving hyper-connectivity to prefrontal cortex and one involving hyper-connectivity to thalamus. Brain regions typically associated with identifying emotion salience were more densely connected with the thalamic hub, consistent with thalamic amplification of prefrontal cortex control of these regions. Additionally, stimuli high in emotional arousal prompted restructuring of the global network to increase clustered processing and overall communication efficiency. These results provide evidence that inhibition of emotion relies on interactions between cognitive control and emotion salience sub-networks.

KW - Connectivity

KW - Emotion

KW - Graph theory

KW - Inhibitory control

KW - fMRI

UR - http://www.scopus.com/inward/record.url?scp=85056764642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056764642&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2018.10.066

DO - 10.1016/j.neuroimage.2018.10.066

M3 - Article

C2 - 30394327

AN - SCOPUS:85056764642

VL - 186

SP - 350

EP - 357

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -