Recent research and emerging challenges in design and optimization for digital microfluidic biochips

Tsung Wei Huang, Yan You Lin, Jia Wen Chang, Tsung Yi Ho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Advances in droplet-based digital microfluidic biochips (DMFBs) have led to the emergence of biochips for automating laboratory procedures in biochemistry and molecular biology. These devices enable the precise control of microliter of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. To meet the challenges of increasing design complexity, computer-aided-design (CAD) tools have been involved to build DMFBs efficiently. This paper provides an overview of DMFBs and describes emerging CAD tools for the automated synthesis and optimization of DMFB designs, from fluidic-level synthesis to chip-level design. Design automations are expected to relieve the design burden of manual optimization of bioassays, time-consuming chip designs, and costly testing and maintenance procedures. With the assistance of CAD tools, users can concentrate on the development and abstraction of nanoscale bioassays while leaving chip optimization and implementation details to CAD tools.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE International SOC Conference, SOCC 2011
Pages12-17
Number of pages6
DOIs
StatePublished - Dec 28 2011
Externally publishedYes
Event24th IEEE International System on Chip Conference, SOCC 2011 - Taipei, Taiwan, Province of China
Duration: Sep 26 2011Sep 28 2011

Publication series

NameInternational System on Chip Conference
ISSN (Print)2164-1676
ISSN (Electronic)2164-1706

Other

Other24th IEEE International System on Chip Conference, SOCC 2011
Country/TerritoryTaiwan, Province of China
CityTaipei
Period9/26/119/28/11

ASJC Scopus subject areas

  • Hardware and Architecture
  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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