TY - GEN
T1 - Recent research and emerging challenges in design and optimization for digital microfluidic biochips
AU - Huang, Tsung Wei
AU - Lin, Yan You
AU - Chang, Jia Wen
AU - Ho, Tsung Yi
PY - 2011/12/28
Y1 - 2011/12/28
N2 - Advances in droplet-based digital microfluidic biochips (DMFBs) have led to the emergence of biochips for automating laboratory procedures in biochemistry and molecular biology. These devices enable the precise control of microliter of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. To meet the challenges of increasing design complexity, computer-aided-design (CAD) tools have been involved to build DMFBs efficiently. This paper provides an overview of DMFBs and describes emerging CAD tools for the automated synthesis and optimization of DMFB designs, from fluidic-level synthesis to chip-level design. Design automations are expected to relieve the design burden of manual optimization of bioassays, time-consuming chip designs, and costly testing and maintenance procedures. With the assistance of CAD tools, users can concentrate on the development and abstraction of nanoscale bioassays while leaving chip optimization and implementation details to CAD tools.
AB - Advances in droplet-based digital microfluidic biochips (DMFBs) have led to the emergence of biochips for automating laboratory procedures in biochemistry and molecular biology. These devices enable the precise control of microliter of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. To meet the challenges of increasing design complexity, computer-aided-design (CAD) tools have been involved to build DMFBs efficiently. This paper provides an overview of DMFBs and describes emerging CAD tools for the automated synthesis and optimization of DMFB designs, from fluidic-level synthesis to chip-level design. Design automations are expected to relieve the design burden of manual optimization of bioassays, time-consuming chip designs, and costly testing and maintenance procedures. With the assistance of CAD tools, users can concentrate on the development and abstraction of nanoscale bioassays while leaving chip optimization and implementation details to CAD tools.
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U2 - 10.1109/SOCC.2011.6085143
DO - 10.1109/SOCC.2011.6085143
M3 - Conference contribution
AN - SCOPUS:84255178642
SN - 9781457716164
T3 - International System on Chip Conference
SP - 12
EP - 17
BT - Proceedings - IEEE International SOC Conference, SOCC 2011
T2 - 24th IEEE International System on Chip Conference, SOCC 2011
Y2 - 26 September 2011 through 28 September 2011
ER -