Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy

Yeling Mei, Ruibo Wang, Wei Jiang, Yang Bo, Tengfei Zhang, Junlin Yu, Ming Cheng, Yunzi Wu, Jianjun Cheng, Wang Ma

Research output: Contribution to journalReview article

Abstract

The combination of gene therapy and immunotherapy has the potential to systemically promote anti-tumor effects while reducing adverse reactions. Small interfering RNA (siRNA) has generated great interest in biology, engineering and medicine, especially for cancer treatment due to its ability to knock down genes of interest. Nanomaterials play significant roles in the design of delivery systems of siRNA, and nanomaterial-mediated siRNA delivery in cancer immunotherapy is one of the most important directions for future clinical cancer treatment. Here, we review the recent advances in nanomaterial mediated targeted delivery of siRNA to dendritic cells (DCs), tumor-associated macrophages (TAMs), immune checkpoint inhibitors, B lymphocytes, natural killer cells (NKs), and immunosuppressive cytokines. Fundamental challenges in nucleic acid delivery enabled by bio-barriers, its promising solution strategies and future directions are also reviewed.

Original languageEnglish (US)
Pages (from-to)2640-2651
Number of pages12
JournalBiomaterials Science
Volume7
Issue number7
DOIs
StatePublished - Jul 2019

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Nucleic acids
RNA
Nanostructured materials
Nucleic Acids
Small Interfering RNA
Oncology
Tumors
Gene therapy
Lymphocytes
Macrophages
Immunosuppressive Agents
Medicine
Genes
Cytokines
Direction compound

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

Cite this

Mei, Y., Wang, R., Jiang, W., Bo, Y., Zhang, T., Yu, J., ... Ma, W. (2019). Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy. Biomaterials Science, 7(7), 2640-2651. https://doi.org/10.1039/c9bm00214f

Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy. / Mei, Yeling; Wang, Ruibo; Jiang, Wei; Bo, Yang; Zhang, Tengfei; Yu, Junlin; Cheng, Ming; Wu, Yunzi; Cheng, Jianjun; Ma, Wang.

In: Biomaterials Science, Vol. 7, No. 7, 07.2019, p. 2640-2651.

Research output: Contribution to journalReview article

Mei, Y, Wang, R, Jiang, W, Bo, Y, Zhang, T, Yu, J, Cheng, M, Wu, Y, Cheng, J & Ma, W 2019, 'Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy', Biomaterials Science, vol. 7, no. 7, pp. 2640-2651. https://doi.org/10.1039/c9bm00214f
Mei, Yeling ; Wang, Ruibo ; Jiang, Wei ; Bo, Yang ; Zhang, Tengfei ; Yu, Junlin ; Cheng, Ming ; Wu, Yunzi ; Cheng, Jianjun ; Ma, Wang. / Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy. In: Biomaterials Science. 2019 ; Vol. 7, No. 7. pp. 2640-2651.
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