Abstract
In recent years, there has been a great deal of interest in the preparation and application of nanoparticles for cancer therapy. Gold nanoparticles are especially suited to thermal destruction of cancer due to their ease of surface functionalization and photothermal heating ability. Here, we review recent progress in gold nanoparticle-mediated thermal cancer therapies. We begin with an introduction to the properties of gold nanoparticles and heat-generating mechanisms which have been established. The pioneering work in photothermal therapy is discussed along with the effects of photothermal heating on cells in vitro. Additionally, radiofrequency-mediated thermal therapy is reviewed. We focus our discussion on the developments and progress in nanoparticle design for photothermal cancer therapy since 2010. This includes in vitro and in vivo studies and the recent progression of gold nanoparticle photothermal therapy toward clinical cancer treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4691-4716 |
| Number of pages | 26 |
| Journal | Journal of Physical Chemistry C |
| Volume | 120 |
| Issue number | 9 |
| DOIs | |
| State | Published - Mar 10 2016 |
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ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Energy(all)
- Physical and Theoretical Chemistry
- Surfaces, Coatings and Films
Cite this
Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles. / Abadeer, Nardine S.; Murphy, Catherine J.
In: Journal of Physical Chemistry C, Vol. 120, No. 9, 10.03.2016, p. 4691-4716.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles
AU - Abadeer, Nardine S.
AU - Murphy, Catherine J.
PY - 2016/3/10
Y1 - 2016/3/10
N2 - In recent years, there has been a great deal of interest in the preparation and application of nanoparticles for cancer therapy. Gold nanoparticles are especially suited to thermal destruction of cancer due to their ease of surface functionalization and photothermal heating ability. Here, we review recent progress in gold nanoparticle-mediated thermal cancer therapies. We begin with an introduction to the properties of gold nanoparticles and heat-generating mechanisms which have been established. The pioneering work in photothermal therapy is discussed along with the effects of photothermal heating on cells in vitro. Additionally, radiofrequency-mediated thermal therapy is reviewed. We focus our discussion on the developments and progress in nanoparticle design for photothermal cancer therapy since 2010. This includes in vitro and in vivo studies and the recent progression of gold nanoparticle photothermal therapy toward clinical cancer treatment.
AB - In recent years, there has been a great deal of interest in the preparation and application of nanoparticles for cancer therapy. Gold nanoparticles are especially suited to thermal destruction of cancer due to their ease of surface functionalization and photothermal heating ability. Here, we review recent progress in gold nanoparticle-mediated thermal cancer therapies. We begin with an introduction to the properties of gold nanoparticles and heat-generating mechanisms which have been established. The pioneering work in photothermal therapy is discussed along with the effects of photothermal heating on cells in vitro. Additionally, radiofrequency-mediated thermal therapy is reviewed. We focus our discussion on the developments and progress in nanoparticle design for photothermal cancer therapy since 2010. This includes in vitro and in vivo studies and the recent progression of gold nanoparticle photothermal therapy toward clinical cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=84960873970&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960873970&partnerID=8YFLogxK
U2 - 10.1021/acs.jpcc.5b11232
DO - 10.1021/acs.jpcc.5b11232
M3 - Review article
AN - SCOPUS:84960873970
VL - 120
SP - 4691
EP - 4716
JO - Journal of Physical Chemistry C
JF - Journal of Physical Chemistry C
SN - 1932-7447
IS - 9
ER -