Recent advances in PRRS virus receptors and the targeting of receptor-ligand for control

Research output: Contribution to journalReview articlepeer-review

Abstract

Cellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, sialoadhesin (CD)163, a cysteine-rich scavenger receptor on macrophages, is the major receptor for PRRSV. This review discusses the recent advances and understanding of the entry of PRRSV into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor-ligand for the control of PRRS.

Original languageEnglish (US)
Article number354
JournalVaccines
Volume9
Issue number4
DOIs
StatePublished - Apr 2021

Keywords

  • CD163
  • PRRSV
  • Porcine reproductive and respiratory syndrome
  • Receptor

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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