Recent advances in natural product discovery

Yunzi Luo, Ryan E. Cobb, Huimin Zhao

Research output: Contribution to journalReview article

Abstract

Natural products have been and continue to be the source and inspiration for a substantial fraction of human therapeutics. Although the pharmaceutical industry has largely turned its back on natural product discovery efforts, such efforts continue to flourish in academia with promising results. Natural products have traditionally been identified from a top-down perspective, but more recently genomics- and bioinformatics-guided bottom-up approaches have provided powerful alternative strategies. Here we review recent advances in natural product discovery from both angles, including diverse sampling and innovative culturing and screening approaches, as well as genomics-driven discovery and genetic manipulation techniques for both native and heterologous expression.

Original languageEnglish (US)
Pages (from-to)230-237
Number of pages8
JournalCurrent Opinion in Biotechnology
Volume30
DOIs
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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