Recent advances in domesticating non-model microorganisms

Zia Fatma, J. Carl Schultz, Huimin Zhao

Research output: Contribution to journalReview articlepeer-review


Non-model microorganisms have been increasingly explored as microbial cell factories for production of chemicals, fuels, and materials owing to their unique physiology and metabolic capabilities. However, these microorganisms often lack facile genetic tools for strain development, which hinders their adoption as production hosts. In this review, we describe recent advances in domestication of non-model microorganisms, including bacteria, actinobacteria, cyanobacteria, yeast, and fungi, with a focus on the development of genetic tools. In addition, we highlight some successful applications of non-model microorganisms as microbial cell factories.

Original languageEnglish (US)
Article numbere3008
JournalBiotechnology Progress
Issue number5
StatePublished - Sep 1 2020


  • genetic elements
  • metabolic engineering
  • non-model microorganism
  • synthetic biology

ASJC Scopus subject areas

  • Biotechnology


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