TY - JOUR
T1 - Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
AU - Jiang, Yunjiang
AU - Chen, Yingying
AU - Song, Ziyuan
AU - Tan, Zhengzhong
AU - Cheng, Jianjun
N1 - Funding Information:
This work was supported by National Science Foundation ( CHE 1709820 ).
Publisher Copyright:
© 2021
PY - 2021/3
Y1 - 2021/3
N2 - The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have sounded a piercing alarm for the need of new effective antimicrobial agents to guard public health. Among different types of candidates, antimicrobial peptides (AMPs) and the synthetic mimics of AMPs (SMAMPs) have attracted significant enthusiasm in the past thirty years, due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. The extensive research has brought many drug candidates into clinical and pre-clinical development. Despite tremendous progresses have been made, several major challenges inherent to current design strategies have slowed down the clinical translational development of AMPs and SMAMPs. However, these challenges also triggered many efforts to redesign and repurpose AMPs. In this review, we will first give an overview on AMPs and their synthetic mimics, and then discuss the current status of their clinical translation. Finally, the recent advances in redesign and repurposing AMPs and SMAMPs are highlighted.
AB - The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have sounded a piercing alarm for the need of new effective antimicrobial agents to guard public health. Among different types of candidates, antimicrobial peptides (AMPs) and the synthetic mimics of AMPs (SMAMPs) have attracted significant enthusiasm in the past thirty years, due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. The extensive research has brought many drug candidates into clinical and pre-clinical development. Despite tremendous progresses have been made, several major challenges inherent to current design strategies have slowed down the clinical translational development of AMPs and SMAMPs. However, these challenges also triggered many efforts to redesign and repurpose AMPs. In this review, we will first give an overview on AMPs and their synthetic mimics, and then discuss the current status of their clinical translation. Finally, the recent advances in redesign and repurposing AMPs and SMAMPs are highlighted.
KW - Antibiotic resistance
KW - Antimicrobial peptides
KW - Clinical translation
KW - Combination therapy
KW - Infection-responsive peptides
KW - Membrane-active antimicrobial mechanism
KW - Nano-antimicrobials
KW - Radially amphiphilic conformation
KW - Small synthetic mimics of antimicrobial peptides
UR - http://www.scopus.com/inward/record.url?scp=85099837109&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85099837109&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2020.12.016
DO - 10.1016/j.addr.2020.12.016
M3 - Article
C2 - 33400958
AN - SCOPUS:85099837109
SN - 0169-409X
VL - 170
SP - 261
EP - 280
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -