Recent advances in chemical dearomatization of nonactivated arenes

William C. Wertjes, Emma H. Southgate, David Sarlah

Research output: Contribution to journalReview articlepeer-review


Dearomatization reactions provide a synthetic connection between readily available, simple aromatic starting materials and more saturated intermediates of greater molecular complexity and synthetic utility. The last decade has witnessed a steady increase in the development of dearomative methods, providing new synthetic approaches to high-value building blocks and natural products. This review highlights advances both in the area of dearomatization methodologies for the most chemically inert arenes and in synthetic applications of such strategies.

Original languageEnglish (US)
Pages (from-to)7996-8017
Number of pages22
JournalChemical Society Reviews
Issue number21
StatePublished - Nov 7 2018

ASJC Scopus subject areas

  • General Chemistry


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