Recent advances in biological production of sugar alcohols

Yong Cheol Park, Eun Joong Oh, Jung Hyun Jo, Yong Su Jin, Jin Ho Seo

Research output: Contribution to journalReview articlepeer-review


Sugar alcohols, such as xylitol, mannitol, sorbitol, and erythritol are emerging food ingredients that provide similar or better sweetness/sensory properties of sucrose, but are less calorigenic. Also, sugar alcohols can be converted into commodity chemicals through chemical catalysis. Biotechnological production offers the safe and sustainable supply of sugar alcohols from renewable biomass. In contrast to early studies that aimed to produce sugar alcohols with microorganisms capable of producing sugar alcohols naturally, recent studies have focused on rational engineering of metabolic pathways to improve yield and productivity as well as to use inexpensive and abundant substrates. Metabolic engineering strategies to utilize inexpensive substrates, alleviate catabolite repression, reduce byproduct formation, and manipulate redox balances led to enhanced production of sugar alcohols.

Original languageEnglish (US)
Pages (from-to)105-113
Number of pages9
JournalCurrent Opinion in Biotechnology
StatePublished - Feb 1 2016

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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