@article{2b4a746863fb4a61954ad846fcf00d68,
title = "Recent Advances and Future Perspectives of Synthetic Polypeptides from N-Carboxyanhydrides",
abstract = "Synthetic polypeptides, the analogues of natural proteins, are important biomaterials that have found broad biomedical applications. Ring-opening polymerization of N-carboxyanhydrides offers a reliable way to prepare high-molecular-weight polypeptides in large scale with diverse side-chain functionalities. The past two decades have seen significant advances in the polypeptide field, with the development of various controlled polymerization methodologies, the deeper understanding on secondary structures, and the discovery of new assembly behaviors and applications. In this Perspective, we highlight several key advances in the chemical synthesis and materials application of synthetic polypeptides and discuss promising future directions in this area.",
author = "Ziyuan Song and Zhengzhong Tan and Jianjun Cheng",
note = "Funding Information: The authors thank and acknowledge the financial support from National Science Foundation (CHE-1709820). Funding Information: Jianjun Cheng obtained his BS degree in Chemistry in 1993 from Nankai University, his MS degree in Chemistry in 1996 from Southern Illinois University at Carbondale, and his PhD degree in Materials Science in 2001 from the University of California, Santa Barbara. He worked as a Senior Scientist at Insert Therapeutics, Inc., from 2001 to 2004 and did his postdoctoral research at MIT from 2004 to 2005. He is currently the Hans Thurnauer Professor of Materials Science and Engineering at the University of Illinois at Urbana–Champaign. He received the National Science Foundation CAREER Award and NIH Director{\textquoteright}s New Innovator Award. He is an Associate Editor of Biomaterials Science, Royal Society of Chemistry. He is a Fellow of the American Institute for Medical and Biological Engineering, American Chemical Society-Division of Polymer Chemistry, and the American Association for the Advancement of Science. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = nov,
day = "26",
doi = "10.1021/acs.macromol.9b01450",
language = "English (US)",
volume = "52",
pages = "8521--8539",
journal = "Macromolecules",
issn = "0024-9297",
publisher = "American Chemical Society",
number = "22",
}