Abstract

Synthetic polypeptides, the analogues of natural proteins, are important biomaterials that have found broad biomedical applications. Ring-opening polymerization of N-carboxyanhydrides offers a reliable way to prepare high-molecular-weight polypeptides in large scale with diverse side-chain functionalities. The past two decades have seen significant advances in the polypeptide field, with the development of various controlled polymerization methodologies, the deeper understanding on secondary structures, and the discovery of new assembly behaviors and applications. In this Perspective, we highlight several key advances in the chemical synthesis and materials application of synthetic polypeptides and discuss promising future directions in this area.

Original languageEnglish (US)
Pages (from-to)8521-8539
Number of pages19
JournalMacromolecules
Volume52
Issue number22
DOIs
StatePublished - Nov 26 2019

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Polypeptides
Peptides
Ring opening polymerization
Biocompatible Materials
Biomaterials
Molecular weight
Polymerization
Proteins

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Recent Advances and Future Perspectives of Synthetic Polypeptides from N-Carboxyanhydrides. / Song, Ziyuan; Tan, Zhengzhong; Cheng, Jianjun.

In: Macromolecules, Vol. 52, No. 22, 26.11.2019, p. 8521-8539.

Research output: Contribution to journalReview article

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AB - Synthetic polypeptides, the analogues of natural proteins, are important biomaterials that have found broad biomedical applications. Ring-opening polymerization of N-carboxyanhydrides offers a reliable way to prepare high-molecular-weight polypeptides in large scale with diverse side-chain functionalities. The past two decades have seen significant advances in the polypeptide field, with the development of various controlled polymerization methodologies, the deeper understanding on secondary structures, and the discovery of new assembly behaviors and applications. In this Perspective, we highlight several key advances in the chemical synthesis and materials application of synthetic polypeptides and discuss promising future directions in this area.

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