Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

John T. Whitteck; Weijuan Ni; Benjamin M. Griffin; Andrew C. Eliot; Paul M. Thomas; Neil L. Kelleher; William W. Metcalf; Wilfred A. Van Der Donk

doi:10.1002/anie.200703810

Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

John T. Whitteck, Weijuan Ni, Benjamin M. Griffin, Andrew C. Eliot, Paul M. Thomas, Neil L. Kelleher, William W. Metcalf, Wilfred A. Van Der Donk

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus, has proven quite elusive. Originally reported as 1 and later revised to 2, the actual structure of the compound is the unusual dehydro aminophosphonic acid 3.

Original language	English (US)
Pages (from-to)	9089-9092
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	47
DOIs	https://doi.org/10.1002/anie.200703810
State	Published - 2007

Keywords

Antibiotics
Biosynthesis
NMR spectroscopy
Phosphonate
Structure elucidation

ASJC Scopus subject areas

Catalysis
General Chemistry

Online availability

10.1002/anie.200703810

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abstract = "(Chemical Equation Presented) Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus, has proven quite elusive. Originally reported as 1 and later revised to 2, the actual structure of the compound is the unusual dehydro aminophosphonic acid 3.",

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AU - Thomas, Paul M.

AU - Kelleher, Neil L.

AU - Metcalf, William W.

AU - Van Der Donk, Wilfred A.

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AB - (Chemical Equation Presented) Third time's the charm! The structure of the phosphonate antibiotic A53868, first isolated in 1983 from Streptomyces luridus, has proven quite elusive. Originally reported as 1 and later revised to 2, the actual structure of the compound is the unusual dehydro aminophosphonic acid 3.

KW - Antibiotics

KW - Biosynthesis

KW - NMR spectroscopy

KW - Phosphonate

KW - Structure elucidation

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Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

Abstract

Keywords

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