Realizations of kinetic differential equations

  • Gheorghe Craciun
  • , Matthew D. Johnston
  • , Gábor Szederkényi
  • , Elisa Tonello
  • , János Tóth
  • , Polly Y. Yu

Research output: Contribution to journalArticlepeer-review

Abstract

The induced kinetic differential equations of a reaction network endowed with mass action type kinetics is a system of polynomial differential equations. The problem studied here is: Given a system of polynomial differential equations, is it possible to find a network which induces these equations; in other words: is it possible to find a kinetic realization of this system of differential equations? If yes, can we find a network with some chemically relevant properties (implying also important dynamic consequences), such as reversibility, weak reversibility, zero deficiency, detailed balancing, complex balancing, mass conservation, etc.? The constructive answers presented to a series of questions of the above type are useful when fitting differential equations to datasets, or when trying to find out the dynamic behavior of the solutions of differential equations. It turns out that some of these results can be applied when trying to solve seemingly unrelated mathematical problems, like the existence of positive solutions to algebraic equations.

Original languageEnglish (US)
Pages (from-to)862-892
Number of pages31
JournalMathematical Biosciences and Engineering
Volume17
Issue number1
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • Kinetic equations
  • Mass action kinetics
  • Reaction networks
  • Realizations
  • Reversibility
  • Weak reversibility

ASJC Scopus subject areas

  • Modeling and Simulation
  • General Agricultural and Biological Sciences
  • Computational Mathematics
  • Applied Mathematics

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