Real-Time Visualization of a Focused Ultrasound Beam Using Ultrasonic Backscatter

Miles Thies, Michael L. Oelze

Research output: Contribution to journalArticlepeer-review


Focused ultrasound (FUS) therapies induce therapeutic effects in localized tissues using either temperature elevations or mechanical stresses caused by an ultrasound wave. During an FUS therapy, it is crucial to continuously monitor the position of the FUS beam in order to correct for tissue motion and keep the focus within the target region. Toward the goal of achieving real-time monitoring for FUS therapies, we have developed a method for the real-time visualization of an FUS beam using ultrasonic backscatter. The intensity field of an FUS beam was reconstructed using backscatter from an FUS pulse received by an imaging array and then overlaid onto a B-mode image captured using the same imaging array. The FUS beam visualization allows one to monitor the position and extent of the FUS beam in the context of the surrounding medium. Variations in the scattering properties of the medium were corrected in the FUS beam reconstruction by normalizing based on the echogenicity of the coaligned B-mode image. On average, normalizing by echogenicity reduced the mean square error between FUS beam reconstructions in nonhomogeneous regions of a phantom and baseline homogeneous regions by 21.61. FUS beam visualizations were achieved, using a single diagnostic imaging array as both an FUS source and an imaging probe, in a tissue-mimicking phantom and a rat tumor in vivo with a frame rate of 25-30 frames/s.

Original languageEnglish (US)
Article number9248051
Pages (from-to)1213-1223
Number of pages11
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Issue number4
StatePublished - Apr 2021


  • Beam visualization
  • focused ultrasound (FUS)
  • real-time
  • therapy monitoring

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering


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