@inproceedings{3fe17fc2b630458db751206af5daaf79,
title = "Real-time visualization of a focused ultrasound beam using ultrasonic backscatter for monitoring of mechanical-based therapies",
abstract = "Mechanical-based focused ultrasound (FUS) therapies use mechanical interactions between an ultrasound wave and tissue to produce localized bioeffects. Although it is a promising therapeutic modality, mechanical-based FUS is limited due to a lack of cost-effective techniques to monitor the FUS beam in real-time during therapy. In this study, we present a technique for the real-time visualization of a FUS beam using ultrasonic backscatter, which could used for the qualitative monitoring of mechanical-based FUS therapies. A diagnostic imaging array was used to transmit a focused visualization pulse and the scattered signal was processed to reconstruct the intensity field of the FUS beam. The imaging array then captured a B-mode image that was registered with the beam reconstruction. The FUS beam reconstruction was superimposed onto the co-aligned B-mode image, allowing one to monitor the location of the FUS beam relative to anatomical information in the B-mode image. The effects of the echogenicity of the medium on the FUS beam reconstruction were reduced using an intensity mask derived from the B-mode image. FUS beam visualizations were demonstrated in a tissue-mimicking phantom and in vivo at a frame rate of 25-30 frames per second.",
keywords = "Beam visualization, Focused ultrasound, Image guidance, Mechanical-based therapies",
author = "Miles Thies and Oelze, {Michael L.}",
note = "This work was supported by the NIH under Grant R21EB023403.; 2020 IEEE International Ultrasonics Symposium, IUS 2020 ; Conference date: 07-09-2020 Through 11-09-2020",
year = "2020",
month = sep,
day = "7",
doi = "10.1109/IUS46767.2020.9251686",
language = "English (US)",
series = "IEEE International Ultrasonics Symposium, IUS",
publisher = "IEEE Computer Society",
booktitle = "IUS 2020 - International Ultrasonics Symposium, Proceedings",
}