Real-time snapshot hyperspectral imaging endoscope

Robert T. Kester, Noah Bedard, Liang Gao, Tomasz S. Tkaczyka

Research output: Contribution to journalArticlepeer-review


Hyperspectral imaging has tremendous potential to detect important molecular biomarkers of early cancer based on their unique spectral signatures. Several drawbacks have limited its use for in vivo screening applications: most notably the poor temporal and spatial resolution, high expense, and low optical throughput of existing hyperspectral imagers. We present the development of a new real-time hyperspectral endoscope (called the image mapping spectroscopy endoscope) based on an image mapping technique capable of addressing these challenges. The parallel high throughput nature of this technique enables the device to operate at frame rates of 5.2 frames per second while collecting a (x, y, λ) datacube of 350 × 350 × 48. We have successfully imaged tissue in vivo, resolving a vasculature pattern of the lower lip while simultaneously detecting oxy-hemoglobin.

Original languageEnglish (US)
Article number056005
JournalJournal of biomedical optics
Issue number5
StatePublished - May 2011
Externally publishedYes


  • Endoscope
  • Hyperspectral
  • Imaging spectrometer
  • Multispectral

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


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