Some metal oxide nanostructured particles have been shown to be effective in detoxification of and clearing smoke in indoor spaces. Such application may involve aerosolization of these particles into the affected space to scavenge unwanted entities. This research was conducted to characterize two types of metal oxide nanostructured particles, which differed in their effectiveness in clearing smoke. Each of the particles was aerosolized through a pressurized canister into an enclosed experimental chamber. The size distribution, number concentration, and mass concentration of the particles inside the chamber were monitored. Results showed that the two nanostructured materials differed in terms of the evolution of the size distribution and decay in concentration.