Real-time detection of protein-water dynamics upon protein folding by terahertz absorption spectroscopy

Seung Joong Kim, Benjamin Born, Martina Havenith, Martin Gruebele

Research output: Contribution to journalArticlepeer-review

Abstract

Take a look around: Kinetic terahertz absorption (KITA) spectroscopy has been used to monitor the attenuation and phase shift of a terahertz electric field transmitted through a protein during refolding. Comparison with data from fluorescence, circular dichroism, and small angle X-ray scattering shows that KITA monitors rearrangements of the hydration water-protein interactions during early collapse and secondary structure formation. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)6486-6489
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number34
DOIs
StatePublished - Aug 11 2008

Keywords

  • Circular dichroism
  • Fluorescence
  • Protein folding
  • Secondary structure
  • Terahertz spectroscopy

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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