Real-time detection of protein-water dynamics upon protein folding by terahertz absorption spectroscopy

Seung Joong Kim; Benjamin Born; Martina Havenith; Martin Gruebele

doi:10.1002/anie.200802281

Real-time detection of protein-water dynamics upon protein folding by terahertz absorption spectroscopy

Seung Joong Kim, Benjamin Born, Martina Havenith, Martin Gruebele

Research output: Contribution to journal › Article › peer-review

Abstract

Take a look around: Kinetic terahertz absorption (KITA) spectroscopy has been used to monitor the attenuation and phase shift of a terahertz electric field transmitted through a protein during refolding. Comparison with data from fluorescence, circular dichroism, and small angle X-ray scattering shows that KITA monitors rearrangements of the hydration water-protein interactions during early collapse and secondary structure formation. (Figure Presented).

Original language	English (US)
Pages (from-to)	6486-6489
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	34
DOIs	https://doi.org/10.1002/anie.200802281
State	Published - Aug 11 2008

Keywords

Circular dichroism
Fluorescence
Protein folding
Secondary structure
Terahertz spectroscopy

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200802281

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abstract = "Take a look around: Kinetic terahertz absorption (KITA) spectroscopy has been used to monitor the attenuation and phase shift of a terahertz electric field transmitted through a protein during refolding. Comparison with data from fluorescence, circular dichroism, and small angle X-ray scattering shows that KITA monitors rearrangements of the hydration water-protein interactions during early collapse and secondary structure formation. (Figure Presented).",

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AU - Born, Benjamin

AU - Havenith, Martina

AU - Gruebele, Martin

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AB - Take a look around: Kinetic terahertz absorption (KITA) spectroscopy has been used to monitor the attenuation and phase shift of a terahertz electric field transmitted through a protein during refolding. Comparison with data from fluorescence, circular dichroism, and small angle X-ray scattering shows that KITA monitors rearrangements of the hydration water-protein interactions during early collapse and secondary structure formation. (Figure Presented).

KW - Circular dichroism

KW - Fluorescence

KW - Protein folding

KW - Secondary structure

KW - Terahertz spectroscopy

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JF - Angewandte Chemie - International Edition

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Real-time detection of protein-water dynamics upon protein folding by terahertz absorption spectroscopy

Abstract

Keywords

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