Real-time detection of airborne viruses on a mass-sensitive device

Joonhyung Lee; Jaesung Jang; Demir Akin; Cagri A. Savran; Rashid Bashir

doi:10.1063/1.2956679

Real-time detection of airborne viruses on a mass-sensitive device

Joonhyung Lee, Jaesung Jang, Demir Akin, Cagri A. Savran, Rashid Bashir

Research output: Contribution to journal › Article › peer-review

Abstract

We present real-time detection of airborne Vaccinia viruses using quartz crystal microbalance (QCM) in an integrated manner. Vaccinia viruses were aerosolized and neutralized using an electrospray aerosol generator, transported into the QCM chamber, and captured by a QCM crystal. The capture of the viruses on the QCM crystal resulted in frequency shifts proportional to the number of viruses. The capture rate varied linearly with the concentration of initial virus suspensions (8.5× 108 -8.5× 1010 particlesml) at flow rates of 2.0 and 1.1 lmin. This work demonstrates the general potential of mass sensitive detection of nanoscale biological entities in air.

Original language	English (US)
Article number	013901
Journal	Applied Physics Letters
Volume	93
Issue number	1
DOIs	https://doi.org/10.1063/1.2956679
State	Published - 2008

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2956679

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abstract = "We present real-time detection of airborne Vaccinia viruses using quartz crystal microbalance (QCM) in an integrated manner. Vaccinia viruses were aerosolized and neutralized using an electrospray aerosol generator, transported into the QCM chamber, and captured by a QCM crystal. The capture of the viruses on the QCM crystal resulted in frequency shifts proportional to the number of viruses. The capture rate varied linearly with the concentration of initial virus suspensions (8.5× 108 -8.5× 1010 particlesml) at flow rates of 2.0 and 1.1 lmin. This work demonstrates the general potential of mass sensitive detection of nanoscale biological entities in air.",

author = "Joonhyung Lee and Jaesung Jang and Demir Akin and Savran, {Cagri A.} and Rashid Bashir",

note = "Funding Information: The authors would like to thank Dr. Stanley Kaufman at TSI for his valuable advices on electrospray aerosol generators and Dr. Debby Sherman for help with SEM imaging. We are also thankful for the financial support of the US National Institute of Health (NIBIB Grant No. R21/R33 EB00778-01). Joonhyung Lee and Jaesung Jang contributed equally to the work. ",

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AU - Bashir, Rashid

N1 - Funding Information: The authors would like to thank Dr. Stanley Kaufman at TSI for his valuable advices on electrospray aerosol generators and Dr. Debby Sherman for help with SEM imaging. We are also thankful for the financial support of the US National Institute of Health (NIBIB Grant No. R21/R33 EB00778-01). Joonhyung Lee and Jaesung Jang contributed equally to the work.

PY - 2008

Y1 - 2008

N2 - We present real-time detection of airborne Vaccinia viruses using quartz crystal microbalance (QCM) in an integrated manner. Vaccinia viruses were aerosolized and neutralized using an electrospray aerosol generator, transported into the QCM chamber, and captured by a QCM crystal. The capture of the viruses on the QCM crystal resulted in frequency shifts proportional to the number of viruses. The capture rate varied linearly with the concentration of initial virus suspensions (8.5× 108 -8.5× 1010 particlesml) at flow rates of 2.0 and 1.1 lmin. This work demonstrates the general potential of mass sensitive detection of nanoscale biological entities in air.

AB - We present real-time detection of airborne Vaccinia viruses using quartz crystal microbalance (QCM) in an integrated manner. Vaccinia viruses were aerosolized and neutralized using an electrospray aerosol generator, transported into the QCM chamber, and captured by a QCM crystal. The capture of the viruses on the QCM crystal resulted in frequency shifts proportional to the number of viruses. The capture rate varied linearly with the concentration of initial virus suspensions (8.5× 108 -8.5× 1010 particlesml) at flow rates of 2.0 and 1.1 lmin. This work demonstrates the general potential of mass sensitive detection of nanoscale biological entities in air.

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Real-time detection of airborne viruses on a mass-sensitive device

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