Real-time corneal segmentation and 3D needle tracking in intrasurgical OCT

Brenton Keller, Mark Draelos, Gao Tang, Sina Farsiu, Anthony N. Kuo, Kris Hauser, Joseph A. Izatt

Research output: Contribution to journalArticlepeer-review


Ophthalmic procedures demand precise surgical instrument control in depth, yet standard operating microscopes supply limited depth perception. Current commercial microscope-integrated optical coherence tomography partially meets this need with manually-positioned cross-sectional images that offer qualitative estimates of depth. In this work, we present methods for automatic quantitative depth measurement using real-time, two-surface corneal segmentation and needle tracking in OCT volumes. We then demonstrate these methods for guidance of ex vivo deep anterior lamellar keratoplasty (DALK) needle insertions. Surgeons using the output of these methods improved their ability to reach a target depth, and decreased their incidence of corneal perforations, both with statistical significance. We believe these methods could increase the success rate of DALK and thereby improve patient outcomes.

Original languageEnglish (US)
Article number#327411
Pages (from-to)2716-2732
Number of pages17
JournalBiomedical Optics Express
Issue number6
StatePublished - Jun 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


Dive into the research topics of 'Real-time corneal segmentation and 3D needle tracking in intrasurgical OCT'. Together they form a unique fingerprint.

Cite this