Over the past several decades, chemists have designed a myriad of supramolecular scaffolds for the purpose of mimicking enzyme behavior and creating more advanced catalysts. Foldamers, one class of supra-molecular structures that feature rapid, modular synthesis and dynamic structural properties and have been widely investigated for their molecular recognition properties. Specifically, our group has designed a reactive w- phenyleneethynylene foldamer, which mimics the selective properties ("reactive sieving") of the isoleucine tRNA synthetase enzyme. In this concept we discuss examples that have inspired our research as well as potential directions for future advancement of this field.

Original languageEnglish (US)
Pages (from-to)2650-2657
Number of pages8
JournalChemistry - A European Journal
Issue number9
StatePublished - Mar 17 2008


  • Cavitands
  • Foldamers
  • Peptide catalysis
  • Supramolecular chemistry
  • Synthetic enzymes

ASJC Scopus subject areas

  • Chemistry(all)

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