Abstract

Neurodegenerative diseases and disorders seriously impact memory and cognition and can become life-threatening. Current medical techniques attempt to combat these detrimental effects mainly through the administration of neuromedicine. However, drug efficacy is limited by rapid dispersal of the drugs to off-target sites while the site of administration is prone to overdose. Many neuropathological conditions are accompanied by excessive reactive oxygen species (ROS) due to the inflammatory response. Accordingly, ROS-responsive drug delivery systems have emerged as a promising solution. To guide intelligent and comprehensive design of ROS-responsive drug delivery systems, this review article discusses the two following topics: (1) the biology of ROS in both healthy and diseased nervous systems and (2) recent developments in ROS-responsive, drug delivery system design. Overall, this review article would assist efforts to make better decisions about designing ROS-responsive, neural drug delivery systems, including the selection of ROS-responsive functional groups.

Original languageEnglish (US)
Article number119292
JournalBiomaterials
Volume217
DOIs
StatePublished - Oct 2019

Fingerprint

Neurodegenerative diseases
Drug Delivery Systems
Neurodegenerative Diseases
Reactive Oxygen Species
Oxygen
Therapeutics
Religious Philosophies
Neurology
Nervous System Diseases
Pharmaceutical Preparations
Cognition
Functional groups
Systems analysis
Data storage equipment

Keywords

  • Drug delivery
  • Neuroinflammation
  • Neurological disorders
  • Reactive oxygen species

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases. / Ballance, William C.; Qin, Ellen C.; Chung, Hee Jung; Gillette, Martha L; Kong, Hyun Joon.

In: Biomaterials, Vol. 217, 119292, 10.2019.

Research output: Contribution to journalReview article

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