Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery

Nathan P. Gabrielson, Hua Lu, Lichen Yin, Dong Li, Fei Wang, Jianjun Cheng

Research output: Contribution to journalArticle

Abstract

At every turn: Poly(γ-(4-vinylbenzyl)-L-glutamate) (PVBLG) is a bioactive and reactive template for a library of cationic α-helical polypeptides (PVBLG n-X) for gene delivery. The top-performing PVBLG n-X outperformed polyethyleneimine (PEI) by 12-fold. Preliminary data indicate that the helicity of the polypeptides is essential for their performance, and enhanced membrane disruption is a likely source of their transfection efficiency. RLU=relative light unit.

Original languageEnglish (US)
Pages (from-to)1143-1147
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number5
DOIs
StatePublished - Jan 27 2012

Fingerprint

Polypeptides
Glutamic Acid
Genes
Peptides
Polyethyleneimine
Membranes

Keywords

  • α-helices
  • drug delivery
  • gene delivery
  • polypeptides
  • stem cells

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery. / Gabrielson, Nathan P.; Lu, Hua; Yin, Lichen; Li, Dong; Wang, Fei; Cheng, Jianjun.

In: Angewandte Chemie - International Edition, Vol. 51, No. 5, 27.01.2012, p. 1143-1147.

Research output: Contribution to journalArticle

Gabrielson, Nathan P. ; Lu, Hua ; Yin, Lichen ; Li, Dong ; Wang, Fei ; Cheng, Jianjun. / Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 5. pp. 1143-1147.
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