Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery

Nathan P. Gabrielson; Hua Lu; Lichen Yin; Dong Li; Fei Wang; Jianjun Cheng

doi:10.1002/anie.201104262

Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery

Nathan P. Gabrielson, Hua Lu, Lichen Yin, Dong Li, Fei Wang, Jianjun Cheng

Research output: Contribution to journal › Article › peer-review

Abstract

At every turn: Poly(γ-(4-vinylbenzyl)-L-glutamate) (PVBLG) is a bioactive and reactive template for a library of cationic α-helical polypeptides (PVBLG _n-X) for gene delivery. The top-performing PVBLG _n-X outperformed polyethyleneimine (PEI) by 12-fold. Preliminary data indicate that the helicity of the polypeptides is essential for their performance, and enhanced membrane disruption is a likely source of their transfection efficiency. RLU=relative light unit.

Original language	English (US)
Pages (from-to)	1143-1147
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	5
DOIs	https://doi.org/10.1002/anie.201104262
State	Published - Jan 27 2012

Keywords

α-helices
drug delivery
gene delivery
polypeptides
stem cells

ASJC Scopus subject areas

General Chemistry
Catalysis

Online availability

10.1002/anie.201104262

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AU - Wang, Fei

AU - Cheng, Jianjun

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AB - At every turn: Poly(γ-(4-vinylbenzyl)-L-glutamate) (PVBLG) is a bioactive and reactive template for a library of cationic α-helical polypeptides (PVBLG n-X) for gene delivery. The top-performing PVBLG n-X outperformed polyethyleneimine (PEI) by 12-fold. Preliminary data indicate that the helicity of the polypeptides is essential for their performance, and enhanced membrane disruption is a likely source of their transfection efficiency. RLU=relative light unit.

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KW - drug delivery

KW - gene delivery

KW - polypeptides

KW - stem cells

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Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery

Abstract

Keywords

ASJC Scopus subject areas

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