Rational and Evolutionary Engineering Approaches Uncover a Small Set of Genetic Changes Efficient for Rapid Xylose Fermentation in Saccharomyces cerevisiae

Medicine & Life Sciences

• Xylose 100%
• Fermentation 80%
• Saccharomyces cerevisiae 69%
• xylose-glucose 27%
• xylulose-5-phosphate 21%
• Acetates 11%
• Sugars 11%
• xylulokinase 10%
• aldehyde dehydrogenase (NAD(P)+) 9%
• Substrate Cycling 9%
• Pentoses 8%
• Xylitol 8%
• Metabolic Engineering 7%
• Plant Cells 7%
• Hexoses 7%
• Complex Mixtures 6%
• Cell Wall 5%
• Phosphoric Monoester Hydrolases 5%
• Carbon 5%
• Ethanol 4%
• Economics 4%
• Genome 3%
• Phenotype 3%
• Mutation 3%
• Enzymes 3%
• Genes 2%

Agriculture & Biology

• xylose 72%
• engineering 67%
• Saccharomyces cerevisiae 62%
• fermentation 53%
• xylulose 13%
• hydrolysates 9%
• glucose 8%
• acetaldehyde dehydrogenase 7%
• acetates 7%
• phosphates 6%
• sugars 6%
• xylitol 5%
• dephosphorylation 5%
• metabolic engineering 5%
• pentoses 5%
• hexoses 5%
• biotransformation 4%
• cell walls 3%
• ethanol 3%
• mutation 3%
• toxicity 3%
• economics 3%
• phenotype 3%
• microorganisms 3%
• carbon 3%
• metabolism 2%
• genome 2%
• extracts 2%
• enzymes 2%
• genes 1%

Chemical Compounds

• Xylose 88%
• Strain 47%
• Xylulose 5-Phosphate 25%
• Glucose 15%
• Metabolic 11%
• Xylitol 9%
• Bioconversion 8%
• Hexose 8%
• Acetaldehyde 6%
• Mixture 6%
• Mutation 5%
• Ethanol 4%
• Carbon Atom 3%
• Reaction Yield 2%