Ratiometric analysis of optical coherence tomography–measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy

Basanta Bhaduri, Ryan L. Shelton, Ryan M. Nolan, Lucas Hendren, Alexandra Almasov, Leanne T. Labriola, Stephen A. Boppart

Research output: Contribution to journalArticlepeer-review

Abstract

Influence of diabetes mellitus (DM) and diabetic retinopathy (DR) on parafoveal retinal thicknesses and their ratios was evaluated. Six retinal layer boundaries were segmented from spectral-domain optical coherence tomography images using open-source software. Five study groups: (1) healthy control (HC) subjects, and subjects with (2) controlled DM, (3) uncontrolled DM, (4) controlled DR and (5) uncontrolled DR, were identified. The one-way analyses of variance (ANOVA) between adjacent study groups (i. e. 1 with 2, 2 with 3, etc) indicated differences in retinal thicknesses and ratios. Overall retinal thickness, ganglion cell layer (GCL) thickness, inner plexiform layer (IPL) thickness, and their combination (GCL+ IPL), appeared to be significantly less in the uncontrolled DM group when compared to controlled DM and controlled DR groups. Although the combination of nerve fiber layer (NFL) and GCL, and IPL thicknesses were not different, their ratio, (NFL+GCL)/IPL, was found to be significantly higher in the controlled DM group compared to the HC group. Comparisons of the controlled DR group with the controlled DM group, and with the uncontrolled DR group, do not show any differences in the layer thicknesses, though several significant ratios were obtained. Ratiometric analysis may provide more sensitive parameters for detecting changes in DR. Picture: A representative segmented OCT image of the human retina is shown.

Original languageEnglish (US)
Pages (from-to)1430-1441
Number of pages12
JournalJournal of Biophotonics
Volume10
Issue number11
DOIs
StatePublished - Nov 2017

Keywords

  • Diabetes mellitus
  • clinical image analysis
  • diabetic retinopathy
  • macula
  • optical coherence tomography
  • retina

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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