The majority of existing wireless rate controls are based on the implicit assumption that frames are corrupted due to the random, arbitrary environmental and thermal noises. They generally reduce the channel rate on frame losses, trading lower efficiency in frequency band utilization for more robust modulation so that the current noise level may be tolerable. In highly interfered wireless networks where frames are lost mainly due to interference from other wireless transceivers, simply reducing the channel rate prolongs the frame transmission time and therefore aggravates frame loss ratio. This positive feedback in the rate control loop quickly diverges the interfered transceivers into asubroutine suboptimal channel rate and drives the network into a state with high interference. In the worst case, interfered transceivers can be starved. In this paper we present RAF, the rate-adaptive framing that jointly controls the channel rate and frame size according to the observed interference patterns and noise level at the receiver. Based on the inputs from physical layer carrier sense, the receiver derives the optimal channel rate and frame size that maximize throughput, and informs the transmitter of such optimal configuration in a few bits in the per-frame acknowledgement. Through intensive simulations we show that RAF consistently outperforms ARF, RBAR, and OAR in all simulated scenarios.